[1] Wentai Liu, Mohanasankar Sivaprakasam, Guoxing Wang, Mingcui Zhou, John Granacki, Jeff LaCoss and Jack Wills, "Implantable Biomimetic Microelectronic Systems Design, IEEE Engineering in Medicine and Biology Magazine, Volume 24, Number 5, September/October 2005.
At a system level, the Mixed-Signal Systems on a Chip Technology Thrust has completed a full set of experiments with the Cortical Testbed on a rat brain slice in vitro and has achieved excellent agreement between the VLSI implementations and the biological CA3 slice response. The second prototype of the single channel VLSI chip was fabricated through MOSIS in TSMC’s 0.18 micron CMOS. This fully tested VLSI implementation includes the real time spike detection circuit and occupies only approximately 1.5 square mm of die area. The VLSI device contains 65K gates and at a clock speed of 5.5 MHz consumes ~2 milliwatts with a throughput of 120 MOPs (24 bits). This result implies that we could integrate 50-100 channels on a single chip. We have also submitted a chip to fabrication that includes the analog processing and Analog-to-Digital Converter integrated together with the digital single-channel model. At a more fundamental research level, we are currently testing a novel charge-metering stimulation amplifier design with the retinal testbed. We are also working with our industrial partners from Texas Instrument to develop Current Mode Logic libraries to further lower the power dissipation of the VLSI design.